Industrial Biocatalysis

Industrial Biocatalysis

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Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.

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Genre : Medical
Author by : Peter Grunwald
Publisher : CRC Press
Release : 2014-12-11
File : 1232 Pages
ISBN : 9789814463898


Handbook Of Industrial Biocatalysis

Handbook Of Industrial Biocatalysis

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Until now, no comprehensive handbook on industrial biocatalysis has been available. Soliciting chapters on virtually every aspect of biocatalysis from international experts most actively researching the field, the Handbook of Industrial Biocatalysis fills this need. The handbook is divided into three sections based on types of substrates. The first section describes the newest biotechnology and bioprocesses for producing industrial products from hydrophobic substrates such as oils and fats. The discussion of biocatalysis covers single and multiple catalytic reactions involved in the creation of products as well as molecular manipulation of enzymes and product recovery. The products include healthy food, nutritional supplements, nutraceuticals, specialty chemicals, surfactants, biopolymers, and antimicrobial agents. The second section covers the production of value-added products from carbohydrate substrates. The scope of this section includes ethanol production, oligosaccharides and glycosides, utilization of hemicelluloses, and carbohydrate-active enzymes. The third section is dedicated to other potential industrial applications such as bioelectrocatalysis for synthesizing chemicals, fuels, and new drugs. The authors explore novel nutrition delivery systems, green chemistry, and the industrial applications of extremophiles. The organizer of several annual worldwide symposia on biocatalysis, editor Ching T. Hou has compiled a cornerstone reference for scientists in academic, industrial, and government research institutes, as well as for graduate-level students involved in biosciences, chemical engineering, biotechnology, microbiology, oil and colloid chemistry, and food chemistry.

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Genre : Science
Author by : Ching T. Hou
Publisher : CRC Press
Release : 2005-06-09
File : 616 Pages
ISBN : 0824724232


Biocatalysis

Biocatalysis

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Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

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Genre : Biocatalysis
Author by : Gonzalo de Gonzalo
Publisher : Royal Society of Chemistry
Release : 2017-11-02
File : 511 Pages
ISBN : 9781782626190


Handbook Of Industrial Biocatalysis

Handbook Of Industrial Biocatalysis

Download

Description:

Until now, no comprehensive handbook on industrial biocatalysis has been available. Soliciting chapters on virtually every aspect of biocatalysis from international experts most actively researching the field, the Handbook of Industrial Biocatalysis fills this need. The handbook is divided into three sections based on types of substrates. T

Details :

Genre : Science
Author by : Ching T. Hou
Publisher : CRC Press
Release : 2005-06-09
File : 616 Pages
ISBN : 9781420027969


Biocatalysis In The Pharmaceutical And Biotechnology Industries

Biocatalysis In The Pharmaceutical And Biotechnology Industries

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Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.

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Genre : Science
Author by : Ramesh N. Patel
Publisher : CRC Press
Release : 2006-09-26
File : 893 Pages
ISBN : 9781420019377


Biocatalysis

Biocatalysis

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The whole range of biocatalysis, from a firm grounding in theoretical concepts to in-depth coverage of practical applications and future perspectives. The book not only covers reactions, products and processes with and from biological catalysts, but also the process of designing and improving such biocatalysts. One unique feature is that the fields of chemistry, biology and bioengineering receive equal attention, thus addressing practitioners and students from all three areas.

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Genre : Science
Author by : Andreas S. Bommarius
Publisher : John Wiley & Sons
Release : 2007-02-27
File : 634 Pages
ISBN : 9783527606054


Biocatalysis For Practitioners

Biocatalysis For Practitioners

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This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

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Genre : Science
Author by : Gonzalo de Gonzalo
Publisher : John Wiley & Sons
Release : 2021-07-19
File : 528 Pages
ISBN : 9783527346837


Biocatalysis For The Pharmaceutical Industry

Biocatalysis For The Pharmaceutical Industry

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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

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Genre : Science
Author by : Junhua (Alex) Tao
Publisher : John Wiley & Sons
Release : 2009-07-23
File : 250 Pages
ISBN : 9780470823156


Applied Biocatalysis

Applied Biocatalysis

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Provides clear and comprehensive coverage of recently developed applied biocatalysis for synthetic organic chemists with an emphasis to promote green chemistry in pharmaceutical and process chemistry This book aims to make biocatalysis more accessible to both academic and industrial synthetic organic chemists. It focuses on current topics within the applied industrial biocatalysis field and includes short but detailed experimental methods on timely novel biocatalytic transformations using new enzymes or new methodologies using known enzymes. The book also features reactions that are “expanding and making the enzyme toolbox available to chemists”—providing readers with comprehensive methodology and detailed key sourcing information of a wide range of enzymes. Chapters in Applied Biocatalysis: The Chemist’s Enzyme Toolkit are organized by reaction type and feature a short introductory section describing the current state of the art for each example. Much of the book focuses on processes for which the enzymes are readily available so that organic chemists can synthesize appropriate quantities of chemicals with available materials in a standard chemical laboratory. Advanced methods are included to present examples of new enzymes that might encourage collaboration with suppliers or academic groups and that will educate chemists of rapidly expanding future possibilities. Focuses on current topics within the applied industrial biocatalysis field Offers experimental methods on novel biocatalytic transformations using new enzymes or new methodology using known enzymes Covers the hot topics of enzyme and chemoenzymatic cascades and biocatalysis in flow Edited by noted experts from both academia and industry with years of experience in the field of biocatalysis—particularly, the industrial applications of enzymes Written for synthetic organic chemists working in all industries but especially the pharmaceutical industry and for those in academia with an eye for biocatalysis, Applied Biocatalysis: The Chemist’s Enzyme Toolkit will also benefit academic groups in chemistry and related sciences that are using enzymes for synthetic purposes, as well as those working in the area of enzymology and molecular biology.

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Genre : Science
Author by : John Whittall
Publisher : John Wiley & Sons
Release : 2020-08-21
File : 560 Pages
ISBN : 9781119487036


Biotechnology Of Microbial Enzymes

Biotechnology Of Microbial Enzymes

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Biotechnology of Microbial Enzymes: Production, Biocatalysis and Industrial Applications provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions. Applications of microbial enzymes in food, feed, and pharmaceutical industries are given particular emphasis. The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last 20 years have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book. Features research on microbial enzymes from basic science through application in multiple industry sectors for a comprehensive approach Includes information on metabolic pathway engineering, metagenomic screening, microbial genomes, extremophiles, rational design, directed evolution, and more Provides a holistic approach to the research of microbial enzymes

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Genre : Medical
Author by : Goutam Brahmachari
Publisher : Academic Press
Release : 2016-07-21
File : 632 Pages
ISBN : 9780128037461